Key result
Unrevascularized post-MI status linked to ~3.3-fold higher 30-day post-PCI mortality versus stable CAD.
Why the study?
Clinical cardiology encompasses a broad spectrum of presentations beyond acute STEMI, motivating a modern, comprehensive appraisal of mortality and MI outcomes following PCI across stable and unstable CAD entities.
Does percutaneous coronary intervention result in different rates of 30-day mortality and myocardial infarction across different clinical presentations of stable and unstable coronary artery disease?
Cohort (n=150)
Yes
Does percutaneous coronary intervention result in different rates of 30-day mortality and myocardial infarction across different clinical presentations of stable and unstable coronary artery disease?
Answers are grounded in this paper and cite their sources.
In this multicenter observational cohort of 150 patients undergoing PCI, 30-day post-PCI mortality varied significantly by underlying CAD subtype—being highest in unrevascularized post-MI (16.7%) and multivessel disease post-STEMI (11.4%) and lowest in stable CAD (5.0%)—whereas post-PCI MI rates did not differ significantly across groups.
Background Acute Coronary Syndrome (ACS) serves as an overarching term encompassing both Unstable Angina (UA) and Myocardial Infarction (MI). Unstable Angina is clinically characterized by the new onset or progressive worsening of anginal chest pain occurring with minimal exertion or at rest, without detectable biochemical evidence of myocardial necrosis. In contrast, classic angina pectoris refers to symptoms resulting from transient myocardial ischemia caused by an imbalance between myocardial oxygen supply and demand. Significance of the study Beyond acute ST-segment Elevation Myocardial Infarction (STEMI), clinical cardiology encompasses a broad spectrum of presentations. This includes post-STEMI patients treated with primary Percutaneous Coronary Intervention (PCI) who retain residual lesions, individuals presenting with Non-ST-segment-Elevation Acute Coronary Syndrome (NSTEACS), and patients post-MI who have not undergone immediate revascularization. At the stable end of this continuum are patients with chronic stable Coronary Artery Disease (CAD). Objectives This inquiry aspires to deliver a modern, comprehensive appraisal of the mortality and MI outcomes consequential to PCI. Our analytical framework adopts a nuanced classification scheme that demarcates between stable and unstable CAD entities.
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Mohammed et al. (2026) conducted a cohort in Coronary artery disease and acute coronary syndrome undergoing percutaneous coronary intervention (n=150). Unstable CAD subtypes (unrevascularized post-MI, multivessel disease post-STEMI, NSTEACS) undergoing PCI vs. Stable CAD undergoing PCI was evaluated on Post-PCI mortality during hospital stay or within 30-day follow-up (p=0.03). Post-PCI 30-day mortality varied by CAD subtype, with the highest rate in unrevascularized post-MI patients compared to stable CAD.
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