Latent cytomegalovirus infection in healthy adults was associated with a significantly increased frequency of autoantibodies to ribonucleoprotein compared to uninfected individuals (84% vs 24%).
Cross-Sectional (n=174)
Yes
Is cytomegalovirus (CMV) infection associated with an autoimmune response to U1 snRNP in healthy individuals and patients with SLE?
CMV infection may play a role in inducing autoimmune responses to U1 snRNP in a subset of patients with systemic lupus erythematosus.
Absolute Event Rate: 84% vs 24%
p-value: p=<0.0001
The induction of autoantibodies to U1 small nuclear ribonucleoprotein (U1 snRNP) complexes is not well understood. We present evidence that healthy individuals with cytomegalovirus (CMV) infection have an increased frequency and quantity of antibodies to ribonucleoprotein, directed primarily against the U1-70k protein. A significant association between the presence of antibodies to CMV and antibodies to the total RNP targeted by the immune response to the spliceosome (to both the Sm and RNP; Sm/RNP) was found for patients with systemic lupus erythematosus (SLE) but not those with mixed connective-tissue disease. CMV thus may play a role in inducing autoimmune responses in a subset of patients with systemic lupus erythematosus.
Newkirk et al. (Thu,) conducted a cross-sectional in Healthy adults and patients with autoimmune diseases (SLE, MCTD) (n=174). Cytomegalovirus (CMV) infection vs. CMV seronegativity was evaluated on Presence of autoantibodies to ribonucleoprotein (RNP) (p=<0.0001). Latent cytomegalovirus infection in healthy adults was associated with a significantly increased frequency of autoantibodies to ribonucleoprotein compared to uninfected individuals (84% vs 24%).
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