Does candesartan alone or in combination with enalapril improve left ventricular remodeling compared to enalapril alone in patients with congestive heart failure?
Patients with congestive heart failure
Candesartan alone or combination of candesartan and enalapril
Enalapril alone
Left ventricular remodeling, effectiveness, safety, and tolerabilitysurrogate
Combining candesartan and enalapril provides greater benefit for preventing left ventricular remodeling in congestive heart failure than either drug alone.
Candesartan alone was as effective, safe, and tolerable as enalapril. The combination of candesartan and enalapril was more beneficial for preventing left ventricular remodeling than either candesartan or enalapril alone.
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Robert S. McKelvie
Salim Yusuf
Dan Pericak
Circulation
Cleveland Clinic
Fred Hutch Cancer Center
Mario Negri Institute for Pharmacological Research
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McKelvie et al. (Tue,) studied this question.
www.synapsesocial.com/papers/69af0aefe03f6d79082a8c72 — DOI: https://doi.org/10.1161/01.cir.100.10.1056
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