Key result
Candesartan plus enalapril beats monotherapy for preventing left ventricular remodeling in heart failure.
Why the study?
Does candesartan alone or in combination with enalapril improve left ventricular remodeling compared to enalapril alone in patients with congestive heart failure?
Does candesartan alone or in combination with enalapril improve left ventricular remodeling compared to enalapril alone in patients with congestive heart failure?
Combining candesartan and enalapril provides greater benefit for preventing left ventricular remodeling in congestive heart failure than either drug alone.
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Does not support dual ARB/ACEi for HF remodeling in practice; leaves open confirmation in larger randomized trials.
McKelvie et al. (1999) studied this question. Candesartan was as effective as enalapril in congestive heart failure, but their combination was more beneficial for preventing left ventricular remodeling than either drug alone.
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