Does the apo B:apo A-I ratio improve prediction of Coronary Heart Disease compared to total cholesterol:HDL-C in men and women?
Men and women in a large, population-based cohort
Measurement of apo B:apo A-I ratio
Traditional lipid ratios (total cholesterol:HDL-C)
Prediction of Coronary Heart Disease (CHD)hard clinical
Apo B and apo A-I measurements do not provide incremental utility over standard total cholesterol and HDL-C for CHD prediction in clinical practice.
In this large, population-based cohort, the overall performance of apo B:apo A-I ratio for prediction of CHD was comparable with that of traditional lipid ratios but did not offer incremental utility over total cholesterol:HDL-C. These data do not support measurement of apo B or apo A-I in clinical practice when total cholesterol and HDL-C measurements are available.
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Erik Ingelsson
Ernst J. Schaefer
John H. Contois
JAMA
Framingham Heart Study
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Ingelsson et al. (Tue,) studied this question.
www.synapsesocial.com/papers/69c08a95a86cbd814171e82f — DOI: https://doi.org/10.1001/jama.298.7.776