Fasting hyperinsulinaemia in lean women with PCOS was associated with menstrual disturbance, hyperandrogenaemia, and correlated positively with IGF-I and negatively with IGFBP-1 concentrations.
Cross-Sectional (n=66)
Does hyperinsulinaemia correlate with endocrine and clinical disturbances in lean and obese women with PCOS?
Fasting hyperinsulinemia is present in lean women with PCOS and correlates with menstrual disturbance, hyperandrogenemia, increased IGF-I, and decreased IGFBP-1.
This study explores the clinical and endocrine implications of hyperinsulinaemia in the polycystic ovary syndrome (PCOS). Oral glucose tolerance tests were performed on 34 lean and 19 obese women with PCOS and on 13 lean women with normal ovaries. Insulin measurements were compared with basal gonadotrophins, androgens, insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein 1 (IGFBP-1). Unselected lean women with PCOS were found to have fasting hyperinsulinaemia and the raised serum insulin concentrations were associated with menstrual disturbance and hyperandrogenaemia. In addition, serum insulin concentrations in lean women with PCOS correlated positively with serum IGF-I and negatively with serum IGFBP-1 concentrations. Ovarian stimulation by insulin appears to be independent of luteinizing hormone (LH) and is an important feature in 30% of lean women with PCOS.
Conway et al. (Thu,) conducted a cross-sectional in Polycystic ovary syndrome (PCOS) (n=66). Hyperinsulinaemia vs. Lean women with normal ovaries was evaluated on Clinical and endocrine implications (menstrual disturbance, hyperandrogenaemia, IGF-I, and IGFBP-1 concentrations). Fasting hyperinsulinaemia in lean women with PCOS was associated with menstrual disturbance, hyperandrogenaemia, and correlated positively with IGF-I and negatively with IGFBP-1 concentrations.