Key result
Fasting hyperinsulinaemia in lean women with PCOS was associated with menstrual disturbance, hyperandrogenaemia, and correlated positively with IGF-I and negatively with IGFBP-1 concentrations.
Why the study?
Does hyperinsulinaemia correlate with endocrine and clinical disturbances in lean and obese women with PCOS?
Cross-Sectional (n=66)
Does hyperinsulinaemia correlate with endocrine and clinical disturbances in lean and obese women with PCOS?
Fasting hyperinsulinemia is present in lean women with PCOS and correlates with menstrual disturbance, hyperandrogenemia, increased IGF-I, and decreased IGFBP-1.
No takes yet. Share an insight, caveat, or question.
May support insulin assessment in lean PCOS; hypothesis-generating for IGF axis role, needing prospective validation.
Conway et al. (1990) conducted a cross-sectional in Polycystic ovary syndrome (PCOS) (n=66). Hyperinsulinaemia vs. Lean women with normal ovaries was evaluated on Clinical and endocrine implications (menstrual disturbance, hyperandrogenaemia, IGF-I, and IGFBP-1 concentrations). Fasting hyperinsulinaemia in lean women with PCOS was associated with menstrual disturbance, hyperandrogenaemia, and correlated positively with IGF-I and negatively with IGFBP-1 concentrations.
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