Enterovirus 71 outbreaks in Japan were associated with central nervous system disorders in 24% of patients in 1973 and 8% of patients in 1978.
Observational
Absolute Event Rate: 24% vs 8%
In Japan we have had two outbreaks of hand, foot, and mouth disease associated with disorders of the central nervous system, one in 1973 and the other in 1978. The isolated virus in both outbreaks was enterovirus 71. Central nervous system disorders were present in 24% of patients in 1973 and in 8% of patients in 1978. These disorders were localised encephalitis with cerebellar signs as the main feature, aseptic meningitis, and polio-like paresis. The enterovirus 71 isolated in Japan had strong dermatotropic as well as neurotropic tendencies. However in cross-neutralisation tests, no difference in antigenicity from the prototype, BrCr strain, was recognised.
ISHIMARU et al. (Fri,) conducted a observational in Hand, foot, and mouth disease. Enterovirus 71 outbreak (1973) vs. Enterovirus 71 outbreak (1978) was evaluated on Central nervous system disorders. Enterovirus 71 outbreaks in Japan were associated with central nervous system disorders in 24% of patients in 1973 and 8% of patients in 1978.