Population
Patients with hand, foot, and mouth disease associated with enterovirus 71 during outbreaks in Japan in 1973…
Design
Cohort
Key result
Enterovirus 71 outbreaks in Japan were associated with central nervous system disorders in 24% of patients in 1973 and 8% of patients in 1978.
Authors
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Past EV71 outbreaks were associated with CNS disorders; leaves open the risk profile of current strains.
Observational
Absolute Event Rate: 24% vs 8%
Enterovirus 71 outbreaks in Japan in 1973 and 1978 were associated with a high incidence of central nervous system complications, including localized encephalitis, aseptic meningitis, and polio-like paresis.
ISHIMARU et al. (1980) conducted an observational in Hand, foot, and mouth disease. Enterovirus 71 outbreak (1973) vs. Enterovirus 71 outbreak (1978) was evaluated on Central nervous system disorders. Enterovirus 71 outbreaks in Japan were associated with central nervous system disorders in 24% of patients in 1973 and 8% of patients in 1978.