The Critical Role of O2 Provision in the Dynamic Adjustment of Oxidative Phosphorylation

In Brief It has been proposed that the adjustment of oxygen uptake (V˙O2) during the exercise on-transient is controlled intracellularly in young healthy individuals and that insufficient local O2 delivery plays a rate-limiting role in aging and disease only. This review shows that adequate O2 provision to the active tissues is critical in the dynamic adjustment of oxidative phosphorylation even in young healthy individuals. This review illustrates the critical role of muscle oxygen delivery in the adjustment of oxidative phosphorylation during the exercise on-transient.