July 2, 2002Open Access

Transforming Growth Factor-β Function Blocking Prevents Myocardial Fibrosis and Diastolic Dysfunction in Pressure-Overloaded Rats

Structured PICO

Does Transforming Growth Factor-β function blocking prevent myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats?

Population

Pressure-overloaded rats

Intervention

Transforming Growth Factor-β (TGF-beta) function blocking

Outcome

Myocardial fibrosis and diastolic dysfunctionsurrogate

Blocking TGF-beta function may serve as a new therapeutic strategy to prevent myocardial fibrosis and diastolic dysfunction in pressure-overloaded hearts.

Abstract

TGF-beta plays a causal role in myocardial fibrosis and diastolic dysfunction through fibroblast activation in pressure-overloaded hearts. Our findings may provide an insight into a new therapeutic strategy to prevent myocardial fibrosis and diastolic dysfunction in pressure-overloaded hearts.

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Cite this study

Kuwahara et al. (Tue,) studied this question.

synapsesocial.com/papers/69d72a80b6c880d6aaf50914 — DOI: https://doi.org/10.1161/01.cir.0000020689.12472.e0

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Authors

Fumitaka Kuwahara

Kurume University

Hisashi Kai

Kurume University

Keisuke Tokuda

Ritsumeikan University

Journals

Circulation

Actions

Institutions

Fukuoka University

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Transforming Growth Factor-β Function Blocking Prevents Myocardial Fibrosis and Diastolic Dysfunction in Pressure-Overloaded Rats

Structured PICO

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Also consider