Does Transforming Growth Factor-β function blocking prevent myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats?
Blocking TGF-beta function may serve as a new therapeutic strategy to prevent myocardial fibrosis and diastolic dysfunction in pressure-overloaded hearts.
TGF-beta plays a causal role in myocardial fibrosis and diastolic dysfunction through fibroblast activation in pressure-overloaded hearts. Our findings may provide an insight into a new therapeutic strategy to prevent myocardial fibrosis and diastolic dysfunction in pressure-overloaded hearts.
Kuwahara et al. (Tue,) studied this question.