Does clopidogrel therapy reduce adverse ischemic events in patients following percutaneous coronary intervention?
Patients following percutaneous coronary intervention (PCI)
Long-term (1-year) clopidogrel therapy and a loading dose of clopidogrel given at least 3 hours before the procedure
Adverse ischemic eventscomposite
Long-term clopidogrel therapy after PCI reduces ischemic events, and longer intervals between a pre-procedure loading dose and PCI may offer additional benefit.
Following PCI, long-term (1-year) clopidogrel therapy significantly reduced the risk of adverse ischemic events. A loading dose of clopidogrel given at least 3 hours before the procedure did not reduce events at 28 days, but subgroup analyses suggest that longer intervals between the loading dose and PCI may reduce events.
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Steven R. Steinhubl
Peter B. Berger
J. Tift Mann
JAMA
University of North Carolina at Chapel Hill
American Medical Association
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Steinhubl et al. (Wed,) studied this question.
www.synapsesocial.com/papers/69da701ba6045d71bfa3cbd3 — DOI: https://doi.org/10.1001/jama.288.19.2411
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