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November 20, 2002JAMA

Early and Sustained Dual Oral Antiplatelet Therapy Following Percutaneous Coronary Intervention

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Why the study?

Does clopidogrel therapy reduce adverse ischemic events in patients following percutaneous coronary intervention?

Population

Patients following percutaneous coronary intervention (PCI)

Design

Review

Follow-up

1 year

Authors

SSSteven R. SteinhublInterventional CardiologyPBPeter B. BergerGeneral CardiologyJMJ. Tift MannUniversity of North Carolina at Chapel Hill

Discussion

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Implication

May support 1-year clopidogrel post-PCI; leaves open optimal loading dose timing for trials.

Structured PICO

Does clopidogrel therapy reduce adverse ischemic events in patients following percutaneous coronary intervention?

P
Population
Patients following percutaneous coronary intervention (PCI)
I
Intervention
Long-term (1-year) clopidogrel therapy and a loading dose of clopidogrel given at least 3 hours before the procedure
O
Outcome
Adverse ischemic eventscomposite

Long-term clopidogrel therapy after PCI reduces ischemic events, and longer intervals between a pre-procedure loading dose and PCI may offer additional benefit.

Cite This Study

Steinhubl et al. (2002) studied this question.

synapsesocial.com/papers/69da701ba6045d71bfa3cbd3https://doi.org/10.1001/jama.288.19.2411

Topics

Dual antiplatelet therapyPercutaneous coronary interventionWomen and heart disease
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Also Consider

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  1. 1Effects of Clopidogrel in Addition to Aspirin in Patients with Acute Coronary Syndromes without ST-Segment Elevation2001 · 6,516 citations
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  3. 3Induction of Cytokine Expression in Leukocytes by Binding of Thrombin-Stimulated Platelets1997 · 383 citations
  4. 4Ticlopidine Pretreatment Before Coronary Stenting Is Associated With Sustained Decrease in Adverse Cardiac Events2001 · 112 citations