Elevated cardiac troponin T independently predicted hospitalization for cardiovascular or cerebrovascular disease in hypertensive patients (HR 6.58; P=0.000001).
Cohort (n=215)
Does elevated cardiac troponin T predict hospitalization due to cardiovascular or cerebrovascular disease in patients with essential hypertension without LV systolic dysfunction?
Elevated cardiac troponin T is a strong, independent predictor of future cardiovascular and cerebrovascular hospitalizations in hypertensive patients without left ventricular systolic dysfunction.
Effect estimate: HR 6.58
p-value: p=0.000001
Ongoing myocardial damage detected as elevated serum cardiac troponin T (cTnT) indicates increased risk for future cardiac events in patients with chronic heart failure. Whether elevated cTnT is associated with adverse outcomes in patients with hypertension (HT) without left ventricular (LV) systolic dysfunction is unknown.We measured cTnT levels in 176 patients with essential HT without LV systolic dysfunction (LV ejection fraction ≤ 55%), renal failure, and prior cardiovascular or cerebrovascular diseases and 39 normal controls. Levels of cTnT were elevated (≥ 0.02 ng/mL) in 15 (9%) of the 176 patients and in 0 (0%) of the 39 normal controls (P = 0.04). The rate of diabetes mellitus (DM), the cardiothoracic ratio, plasma B-type natriuretic peptide (BNP) value, and LV mass index were significantly higher in patients with than without elevated cTnT (DM, 8/15 versus 29/161, P = 0.004; cardiothoracic ratio, 54.5 ± 4.5 versus 51.6 ± 5.2%, P = 0.04; BNP, 103.3 ± 142.3 versus 36.9 ± 50.7 pg/mL, P = 0.04; LV mass index, 227 ± 87 versus 152 ± 57 g/m(2), P = 0.0001). Kaplan-Meier analysis demonstrated that significantly fewer (P < 0.000001) patients with, than without elevated cTnT remained free of events (hospitalization due to cardiovascular or cerebrovascular disease, n = 34). Stepwise Cox multivariate analysis revealed that elevated cTnT (hazard ratio, 6.58; P = 0.000001) and smoking (hazard ratio, 2.24; P = 0.04) were independent predictors of events.The present findings indicate that cTnT is a novel and useful predictor of future cardiovascular or cerebrovascular events in hypertensive patients.
Setsuta et al. (Sat,) conducted a cohort in Essential hypertension (n=215). Elevated cardiac troponin T (≥ 0.02 ng/mL) vs. Normal cardiac troponin T was evaluated on Hospitalization due to cardiovascular or cerebrovascular disease (HR 6.58, p=0.000001). Elevated cardiac troponin T independently predicted hospitalization for cardiovascular or cerebrovascular disease in hypertensive patients (HR 6.58; P=0.000001).