Pulmonary thromboendarterectomy significantly increased left ventricular end-diastolic volume (58.5 to 76.6 ml) and stroke volume (30.3 to 41.8 ml) within 1 week after surgery (P<0.001).
Cohort (n=22)
Does pulmonary thromboendarterectomy improve left ventricular diastolic function in patients with chronic thromboembolic pulmonary hypertension?
Relief of chronic right ventricular pressure overload via pulmonary thromboendarterectomy results in early improvement in left ventricular filling and stroke volume.
Absolute Event Rate: 76.6% vs 58.5%
p-value: p=<0.001
Chronic right ventricular pressure overload is associated with left ventricular diastolic dysfunction. Whether or not an abrupt reduction in pulmonary artery pressure in patients with chronic pulmonary hypertension results in early improvement of left ventricular diastolic function is unknown. To assess this, the Doppler indexes of left ventricular diastolic function and echocardiographic measures of left ventricular volume were analyzed in 22 patients (age, 41 +/- 14 years, mean +/- SD) before and within 1 week after pulmonary thromboendarterectomy for chronic thromboembolic pulmonary hypertension. Mean duration of cardiopulmonary symptoms was 37 months (range, 4 months to 9 years). After operation, mean pulmonary artery pressure and pulmonary vascular resistance decreased (50 +/- 13 to 29 +/- 9 mm Hg and 904 +/- 654 to 283 +/- 243 dynes.sec/cm5, respectively, both p less than 0.001), pulmonary artery wedge pressure was unchanged (11 +/- 5 to 12 +/- 5 mm Hg), and cardiac index increased (2.0 +/- 0.5 to 2.8 +/- 0.7 l/min/m2 p less than 0.001). Left ventricular end-diastolic volume and stroke volume increased significantly (58.5 +/- 18.0 to 76.6 +/- 25.0 ml and 30.3 +/- 12.3 to 41.8 +/- 12.5 ml, respectively, both p less than 0.001) after surgery.(ABSTRACT TRUNCATED AT 250 WORDS)
Dittrich et al. (Sun,) conducted a cohort in Chronic thromboembolic pulmonary hypertension (n=22). Pulmonary thromboendarterectomy vs. Pre-operative baseline was evaluated on Left ventricular end-diastolic volume (ml) (p=<0.001). Pulmonary thromboendarterectomy significantly increased left ventricular end-diastolic volume (58.5 to 76.6 ml) and stroke volume (30.3 to 41.8 ml) within 1 week after surgery (P<0.001).