What is the clinical evidence from this study?

Study design: Cohort. Population: Chronic thromboembolic pulmonary hypertension (n=22). Intervention: Pulmonary thromboendarterectomy vs. Pre-operative baseline. Primary outcome: Left ventricular end-diastolic volume (ml) (p=<0.001).

What question did this study set out to answer?

This study aims to determine if abrupt reduction of pulmonary artery pressure improves left ventricular diastolic function in patients with chronic pulmonary hypertension.

October 1, 1989CirculationOpen Access

Early improvement in left ventricular diastolic function after relief of chronic right ventricular pressure overload.

Q: What are the key findings of this study?

Pulmonary thromboendarterectomy significantly increased left ventricular end-diastolic volume (58.5 to 76.6 ml) and stroke volume (30.3 to 41.8 ml) within 1 week after surgery (P<0.001).

Q: What question did this study set out to answer?

This study aims to determine if abrupt reduction of pulmonary artery pressure improves left ventricular diastolic function in patients with chronic pulmonary hypertension.

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Key result

Pulmonary thromboendarterectomy significantly increased left ventricular end-diastolic volume (58.5 to 76.6 ml) and stroke volume (30.3 to 41.8 ml) within 1 week after surgery (P<0.001).

Why the study?

Does pulmonary thromboendarterectomy improve left ventricular diastolic function in patients with chronic thromboembolic pulmonary hypertension?

Population

22 patients with chronic thromboembolic pulmonary hypertension, mean age 41 +/- 14 years, with mean duration…

Comparison

Pulmonary thromboendarterectomy vs Pre-operative baseline (before surgery)

Design

Cohort

Follow-up

within 1 week after surgery

Authors

HDHoward C. DittrichHeart Failure & Transplant LCLeon C. ChowUnited States Department of Veterans Affairs PNPascal NicodGeneral Cardiology

Discussion

Member takes

Implication

Pulmonary thromboendarterectomy may rapidly improve left ventricular filling in chronic thromboembolic pulmonary hypertension; observational data leaves open causal and outcome confirmation.

Key Points

This study aims to determine if abrupt reduction of pulmonary artery pressure improves left ventricular diastolic function in patients with chronic pulmonary hypertension.
Analyzed Doppler indexes of left ventricular diastolic function and echocardiographic measures in 22 patients before and within 1 week post-surgery.
Patients underwent pulmonary thromboendarterectomy for chronic thromboembolic pulmonary hypertension.
Mean pulmonary artery pressure decreased from 50 +/- 13 to 29 +/- 9 mm Hg (p < 0.001).
Cardiac index increased from 2.0 +/- 0.5 to 2.8 +/- 0.7 l/min/m2 (p < 0.001).
Left ventricular end-diastolic volume and stroke volume increased significantly, with changes from 58.5 +/- 18.0 ml to 76.6 +/- 25.0 ml and 30.3 +/- 12.3 ml to 41.8 +/- 12.5 ml, respectively (both p < 0.001).

Study Design

Type

Cohort (n=22)

Structured PICO

Does pulmonary thromboendarterectomy improve left ventricular diastolic function in patients with chronic thromboembolic pulmonary hypertension?

Population

22 patients (mean age 41 years) with chronic thromboembolic pulmonary hypertension evaluated before and within 1 week after pulmonary thromboendarterectomy.

Exposure

Pulmonary thromboendarterectomy

Comparator

Pre-operative baseline (before surgery)

Outcome

Doppler indexes of left ventricular diastolic function and echocardiographic measures of left ventricular volume within 1 week after surgerysurrogate

Main Result

Absolute Event Rate: 76.6% vs 58.5%

p-value: p=<0.001

Relief of chronic right ventricular pressure overload via pulmonary thromboendarterectomy results in early improvement in left ventricular filling and stroke volume.

Cite This Study

Dittrich et al. (1989) conducted a cohort in Chronic thromboembolic pulmonary hypertension (n=22). Pulmonary thromboendarterectomy vs. Pre-operative baseline was evaluated on Left ventricular end-diastolic volume (ml) (p=<0.001). Pulmonary thromboendarterectomy significantly increased left ventricular end-diastolic volume (58.5 to 76.6 ml) and stroke volume (30.3 to 41.8 ml) within 1 week after surgery (P<0.001).

synapsesocial.com/papers/6a22a4acb67b8d1b1fd2bf89 https://doi.org/10.1161/01.cir.80.4.823

Topics

Pulmonary embolism Echocardiography

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October 1, 1989CirculationOpen Access

Early improvement in left ventricular diastolic function after relief of chronic right ventricular pressure overload.

View Full Paper

Ask AI

Bookmark

Key result

Pulmonary thromboendarterectomy significantly increased left ventricular end-diastolic volume (58.5 to 76.6 ml) and stroke volume (30.3 to 41.8 ml) within 1 week after surgery (P<0.001).

Why the study?

Does pulmonary thromboendarterectomy improve left ventricular diastolic function in patients with chronic thromboembolic pulmonary hypertension?

Population

22 patients with chronic thromboembolic pulmonary hypertension, mean age 41 +/- 14 years, with mean duration…

Comparison

Pulmonary thromboendarterectomy vs Pre-operative baseline (before surgery)

Design

Cohort

Follow-up

within 1 week after surgery

Authors

HDHoward C. DittrichHeart Failure & Transplant LCLeon C. ChowUnited States Department of Veterans Affairs PNPascal NicodGeneral Cardiology

Discussion

Member takes

Implication

Pulmonary thromboendarterectomy may rapidly improve left ventricular filling in chronic thromboembolic pulmonary hypertension; observational data leaves open causal and outcome confirmation.

Key Points

This study aims to determine if abrupt reduction of pulmonary artery pressure improves left ventricular diastolic function in patients with chronic pulmonary hypertension.
Analyzed Doppler indexes of left ventricular diastolic function and echocardiographic measures in 22 patients before and within 1 week post-surgery.
Patients underwent pulmonary thromboendarterectomy for chronic thromboembolic pulmonary hypertension.
Mean pulmonary artery pressure decreased from 50 +/- 13 to 29 +/- 9 mm Hg (p < 0.001).
Cardiac index increased from 2.0 +/- 0.5 to 2.8 +/- 0.7 l/min/m2 (p < 0.001).
Left ventricular end-diastolic volume and stroke volume increased significantly, with changes from 58.5 +/- 18.0 ml to 76.6 +/- 25.0 ml and 30.3 +/- 12.3 ml to 41.8 +/- 12.5 ml, respectively (both p < 0.001).

Study Design

Type

Cohort (n=22)

Structured PICO

Does pulmonary thromboendarterectomy improve left ventricular diastolic function in patients with chronic thromboembolic pulmonary hypertension?

Population

22 patients (mean age 41 years) with chronic thromboembolic pulmonary hypertension evaluated before and within 1 week after pulmonary thromboendarterectomy.

Exposure

Pulmonary thromboendarterectomy

Comparator

Pre-operative baseline (before surgery)

Outcome

Doppler indexes of left ventricular diastolic function and echocardiographic measures of left ventricular volume within 1 week after surgerysurrogate

Main Result

Absolute Event Rate: 76.6% vs 58.5%

p-value: p=<0.001

Relief of chronic right ventricular pressure overload via pulmonary thromboendarterectomy results in early improvement in left ventricular filling and stroke volume.

Cite This Study

synapsesocial.com/papers/6a22a4acb67b8d1b1fd2bf89 https://doi.org/10.1161/01.cir.80.4.823

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

Topics

Pulmonary embolism Echocardiography

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