Endomyocardial fibrosis was present in 60% of patients with aortic stenosis and 40% with aortic regurgitation, correlating with symptoms of cardiac failure and mortality in both groups.
Observational (n=97)
Absolute Event Rate: 60% vs 40%
The amount of fibrosis in endomyocardial biopsies from 55 patients with aortic stenosis and 42 patients with aortic regurgitaion was measured. Sixty per cent of the patients with aortic stenosis had some degree of fibrosis; the degree of fibrosis correlated strongly with ejection fraction, peak systolic gradient, symptoms of cardiac failure, and mortality. In patients with aortic regurgitation, fibrosis was found in 40 per cent and was never severe. A correlation was found with symptoms of cardiac failure and mortality at follow-up, but not with ejection fraction or degree of regurgitation.
Oldershaw et al. (Mon,) conducted a observational in Aortic valve disease (n=97). Aortic stenosis vs. Aortic regurgitation was evaluated on Presence of fibrosis in endomyocardial biopsies. Endomyocardial fibrosis was present in 60% of patients with aortic stenosis and 40% with aortic regurgitation, correlating with symptoms of cardiac failure and mortality in both groups.