Key result
Endomyocardial fibrosis was present in 60% of patients with aortic stenosis and 40% with aortic regurgitation, correlating with symptoms of cardiac failure and mortality in both groups.
Why the study?
Does the degree of fibrosis in endomyocardial biopsies correlate with clinical symptoms, hemodynamics, and mortality in patients with aortic valve disease?
Observational (n=97)
Does the degree of fibrosis in endomyocardial biopsies correlate with clinical symptoms, hemodynamics, and mortality in patients with aortic valve disease?
Absolute Event Rate: 60% vs 40%
Myocardial fibrosis is prevalent in aortic valve disease and correlates with heart failure symptoms and mortality, highlighting its prognostic relevance.
Hypothesis-generating for fibrosis assessment in aortic valve disease; prospective trials needed before clinical adoption.
The amount of fibrosis in endomyocardial biopsies from 55 patients with aortic stenosis and 42 patients with aortic regurgitaion was measured. Sixty per cent of the patients with aortic stenosis had some degree of fibrosis; the degree of fibrosis correlated strongly with ejection fraction, peak systolic gradient, symptoms of cardiac failure, and mortality. In patients with aortic regurgitation, fibrosis was found in 40 per cent and was never severe. A correlation was found with symptoms of cardiac failure and mortality at follow-up, but not with ejection fraction or degree of regurgitation.
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Oldershaw et al. (1980) conducted an observational in Aortic valve disease (n=97). Aortic stenosis vs. Aortic regurgitation was evaluated on Presence of fibrosis in endomyocardial biopsies. Endomyocardial fibrosis was present in 60% of patients with aortic stenosis and 40% with aortic regurgitation, correlating with symptoms of cardiac failure and mortality in both groups.
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