This study highlights the dynamic contribution of monocytes to heart macrophages and their role in myocardial immunosurveillance during steady state and after myocardial infarction.
In this study, we show differential contribution of monocytes to heart macrophages during steady state, after macrophage depletion or in the acute and chronic phase after myocardial infarction. We found that macrophages participate in the immunosurveillance of myocardial tissue. These data correspond with previous studies on tissue-resident macrophages and raise important questions on the fate and function of macrophages during the development of heart failure.
Heidt et al. (Fri,) studied this question.
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