Exogenous nitric oxide donation via glycerine trinitrate can lengthen the course of poliovirus infection in human cell lines, whereas endogenous NO production is insufficient to limit viral productivity.
The role of nitric oxide after poliovirus infection of the human HeLa (carcinoma) and U937 (promonocytic) cell lines has been analyzed. Both types of cells produced detectable levels of nitric oxide after poliovirus infection. However, this production was not sufficient to limit viral productivity. On the other hand, pretreatment with the nitric oxide donor glycerine trinitrate lengthened the course of poliovirus infection.
López‐Guerrero et al. (Sun,) studied this question.