November 16, 2014Open Access
Predictors of blood pressure response in the SYMPLICITY HTN-3 trial
Key Result
Post hoc analyses identified potential confounders influencing blood pressure responses in both sham control and RDN groups in the SYMPLICITY HTN-3 trial.
Structured PICO
What are the predictors of blood pressure response to RDN versus sham control in patients with resistant hypertension?
P
Population
Patients with resistant hypertension
I
Intervention
RDN (renal denervation)
C
Comparator
Sham control
O
Outcome
Blood pressure responsesurrogate
Post hoc analyses of the SYMPLICITY HTN-3 trial identified potential confounding factors that may explain the unexpected blood pressure responses to renal denervation, informing future trial designs.
Main Result
Absolute Event Rate: 0% vs 0%
Abstract
Post hoc analyses, although derived from limited patient cohorts, reveal several potential confounding factors that may partially explain the unexpected blood pressure responses in both the sham control and RDN groups. These hypothesis-generating data further inform the design of subsequent research to evaluate the potential role of RDN in the treatment of resistant hypertension. CLINICALTRIALS.GOV IDENTIFIER: NCT01418261.
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Authors
D
David E. Kandzari
Interventional Cardiology
Deepak L. Bhatt
Mount Sinai Health System
S
Sandeep Brar
Medtronic (Ireland)
Journals
European Heart Journal
Actions
Institutions
Harvard University
University of Pennsylvania
University of Chicago
References and Citations
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