Key result
Post hoc analysis links RDN and sham blood pressure responses to potential confounders.
Why the study?
What are the predictors of blood pressure response to RDN versus sham control in patients with resistant hypertension?
What are the predictors of blood pressure response to RDN versus sham control in patients with resistant hypertension?
Post hoc analyses of the SYMPLICITY HTN-3 trial identified potential confounding factors that may explain the unexpected blood pressure responses to renal denervation, informing future trial designs.
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Confounders may explain SYMPLICITY HTN-3 results; leaves open optimized patient selection and trial designs for renal denervation.
Kandzari et al. (2014) studied this question. Post hoc analyses identified potential confounders influencing blood pressure responses in both sham control and RDN groups in the SYMPLICITY HTN-3 trial.
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