Why the study?
Pre-treatment blood pressure predicts response after renal denervation, but prior efforts to discover further significant and clinically meaningful predictors of response had failed.
Population
266 patients with resistant hypertension undergoing radiofrequency RDN
Comparison
Responders vs non-responders based on excessive 24h systolic ABP decrease
Design
Two-centre observational cohort study
Follow-up
12 months
Key result
In patients with resistant hypertension undergoing renal denervation, lower baseline HbA1c (beta -0.167, p=0.004) and office heart rate were independent predictors of blood pressure decrease.
Authors
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Pre-treatment BP predicts RDN response; leaves open whether additional predictors meaningfully improve patient selection.
Cohort (n=266)
Yes
Absolute Event Rate: -23.3% vs 1.4%
p-value: p=<0.001
In patients with resistant hypertension undergoing renal denervation, lower HbA1c and office heart rate are independent predictors of blood pressure response, in addition to pre-treatment blood pressure.
Schmieder et al. (2021) conducted a cohort in resistant hypertension (n=266). Baseline HbA1c and office heart rate was evaluated on change in 24-hour systolic ambulatory blood pressure after 6 months from pre-treatment values (p=<0.001). In patients with resistant hypertension undergoing renal denervation, lower baseline HbA1c (beta -0.167, p=0.004) and office heart rate were independent predictors of blood pressure decrease.