What does this research mean for the field?

A baseline biomarker profile indicative of higher neurohumoral activation, including elevated plasma renin activity, urinary norepinephrine, neuropeptide Y, and ATP, is associated with a pronounced ambulatory blood pressure reduction following renal denervation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate whether baseline neurohumoral and inflammatory biomarkers correlate with substantial 24-hour ambulatory blood pressure reduction following renal denervation.

September 3, 2026Journal of Clinical HypertensionOpen Access

Neurohumoral Biomarker Profile Associated With Blood Pressure Response After Renal Denervation

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Uncontrolled essential hypertension (n=40). Intervention: Baseline neurohumoral biomarkers (renin, norepinephrine, neuropeptide Y, ATP) vs. Low baseline biomarker levels. Primary outcome: High response (reduction of ≥10 mmHg in 24-h ambulatory systolic blood pressure at 6 months).

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Why the study?

Blood pressure response after renal denervation remains heterogeneous, prompting investigation into whether baseline neurohumoral and inflammation-related biomarkers associate with a pronounced ambulatory response.

Are baseline neurohumoral and inflammation-related biomarkers associated with a pronounced ambulatory blood pressure response after renal denervation in patients with uncontrolled essential hypertension?

Population

40 patients with uncontrolled essential hypertension undergoing RDN in four clinical trial programs

Comparison

High responders (reduction of >=10 mmHg in 24-h ambulatory SBP) vs low responders

Design

Single-center post hoc analysis

Follow-up

6 months

Key result

Higher baseline upright plasma renin activity, 24-h urinary norepinephrine, serum neuropeptide Y, and plasma ATP levels were associated with a pronounced blood pressure response after renal denervation.

Authors

WLWei Liang YWYingdong Wang LALong Ai

Discussion

Member takes

Overview

May identify high responders via neurohumoral profiling; leaves open whether biomarkers improve outcomes in prospective randomized trials.

Key Points

To investigate whether baseline neurohumoral and inflammatory biomarkers correlate with substantial 24-hour ambulatory blood pressure reduction following renal denervation.
Conducted a single-center post hoc analysis of 40 patients with uncontrolled essential hypertension enrolled across four clinical trial programs undergoing renal denervation.
Classified high response as a decrease of ≥10 mmHg in 24-hour ambulatory systolic blood pressure at 6 months post-procedure.
Evaluated candidate baseline biomarkers using logistic regression and receiver operating characteristic analyses.
At 6 months, overall office SBP and DBP fell by 21.57 ± 9.90 and 9.70 ± 9.94 mmHg, while 24-hour ambulatory SBP and DBP fell by 14.38 ± 13.55 and 9.25 ± 8.57 mmHg.
High responders had significantly higher baseline levels of upright plasma renin activity, 24-hour urinary norepinephrine, serum neuropeptide Y, and plasma adenosine triphosphate.
A multivariable model combining these four elevated neurohumoral biomarkers demonstrated high apparent discrimination for identifying high blood pressure responders.

Study Design

Type

Observational (n=40)

Multicenter

Structured PICO

Population

40 patients with uncontrolled essential hypertension who underwent renal denervation, evaluated at 6 months to assess biomarker associations with blood pressure response.

Exposure

Renal denervation (RDN)

Comparator

Low-response group (<10 mmHg reduction in 24-h ambulatory systolic blood pressure at 6 months)

Outcome

High response (reduction of ≥10 mmHg in 24-h ambulatory systolic blood pressure at 6 months)surrogate

A baseline biomarker profile indicating higher neurohumoral activation is associated with a more pronounced ambulatory blood pressure reduction following renal denervation.

Limitations

Validation in larger prospective cohorts is required
Small sample size
Post hoc analysis
Requires validation in larger prospective cohorts

Cite This Study

Liang et al. (2026) conducted an observational in Uncontrolled essential hypertension (n=40). Baseline neurohumoral biomarkers (renin, norepinephrine, neuropeptide Y, ATP) vs. Low baseline biomarker levels was evaluated on High response (reduction of ≥10 mmHg in 24-h ambulatory systolic blood pressure at 6 months). Higher baseline upright plasma renin activity, 24-h urinary norepinephrine, serum neuropeptide Y, and plasma ATP levels were associated with a pronounced blood pressure response after renal denervation.

synapsesocial.com/papers/6a993626636c6408cfa7efcf https://doi.org/10.1111/jch.70352

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September 3, 2026Journal of Clinical HypertensionOpen Access

Neurohumoral Biomarker Profile Associated With Blood Pressure Response After Renal Denervation

View Full Paper

Ask AI

Bookmark

Why the study?

Population

40 patients with uncontrolled essential hypertension undergoing RDN in four clinical trial programs

Comparison

High responders (reduction of >=10 mmHg in 24-h ambulatory SBP) vs low responders

Design

Single-center post hoc analysis

Follow-up

6 months

Key result

Authors

WLWei Liang YWYingdong Wang LALong Ai

Discussion

Member takes

Overview

May identify high responders via neurohumoral profiling; leaves open whether biomarkers improve outcomes in prospective randomized trials.

Key Points

To investigate whether baseline neurohumoral and inflammatory biomarkers correlate with substantial 24-hour ambulatory blood pressure reduction following renal denervation.
Conducted a single-center post hoc analysis of 40 patients with uncontrolled essential hypertension enrolled across four clinical trial programs undergoing renal denervation.
Classified high response as a decrease of ≥10 mmHg in 24-hour ambulatory systolic blood pressure at 6 months post-procedure.
Evaluated candidate baseline biomarkers using logistic regression and receiver operating characteristic analyses.
At 6 months, overall office SBP and DBP fell by 21.57 ± 9.90 and 9.70 ± 9.94 mmHg, while 24-hour ambulatory SBP and DBP fell by 14.38 ± 13.55 and 9.25 ± 8.57 mmHg.
High responders had significantly higher baseline levels of upright plasma renin activity, 24-hour urinary norepinephrine, serum neuropeptide Y, and plasma adenosine triphosphate.
A multivariable model combining these four elevated neurohumoral biomarkers demonstrated high apparent discrimination for identifying high blood pressure responders.

Study Design

Type

Observational (n=40)

Multicenter

Structured PICO

Population

40 patients with uncontrolled essential hypertension who underwent renal denervation, evaluated at 6 months to assess biomarker associations with blood pressure response.

Exposure

Renal denervation (RDN)

Comparator

Low-response group (<10 mmHg reduction in 24-h ambulatory systolic blood pressure at 6 months)

Outcome

High response (reduction of ≥10 mmHg in 24-h ambulatory systolic blood pressure at 6 months)surrogate

A baseline biomarker profile indicating higher neurohumoral activation is associated with a more pronounced ambulatory blood pressure reduction following renal denervation.

Limitations

Validation in larger prospective cohorts is required
Small sample size
Post hoc analysis
Requires validation in larger prospective cohorts

Cite This Study

synapsesocial.com/papers/6a993626636c6408cfa7efcf https://doi.org/10.1111/jch.70352

Also Consider

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