Is relative apical sparing of longitudinal strain using two-dimensional speckle-tracking echocardiography sensitive and specific for diagnosing cardiac amyloidosis?
Patients with cardiac amyloidosis (CA) or other causes of left ventricular hypertrophy
Two-dimensional speckle-tracking echocardiography to assess relative 'apical sparing' pattern of longitudinal strain (LS)
Differentiation of cardiac amyloidosis from other causes of LV hypertrophy (diagnostic sensitivity and specificity)surrogate
Relative apical sparing of longitudinal strain on 2D speckle-tracking echocardiography is an accurate and reproducible marker for diagnosing cardiac amyloidosis.
CA is characterised by regional variations in LS from base to apex. A relative 'apical sparing' pattern of LS is an easily recognisable, accurate and reproducible method of differentiating CA from other causes of LV hypertrophy.
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Dermot Phelan
Patrick Collier
Paaladinesh Thavendiranathan
Heart
Cleveland Clinic
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Phelan et al. (Fri,) studied this question.
www.synapsesocial.com/papers/69df01b2d26790719bedbcb4 — DOI: https://doi.org/10.1136/heartjnl-2012-302353