Does the use of selective COX-2 inhibitors and nonselective NSAIDs increase the risk of death or reinfarction in patients with previous acute myocardial infarction?
Selective COX-2 inhibitors and high-dose nonselective NSAIDs are associated with increased mortality in patients with a history of myocardial infarction and should be used with caution.
Selective COX-2 inhibitors in all dosages and nonselective NSAIDs in high dosages increase mortality in patients with previous MI and should therefore be used with particular caution in these patients.
Gislason et al. (Tue,) studied this question.
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