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Of 1915 patients with OC, 347 (18%) carried pathogenic germline mutations in genes associated with OC risk. PALB2 and BARD1 are suspected OC genes and together with established OC genes (BRCA1, BRCA2, BRIP1, RAD51C, RAD51D, MSH2, MLH1, PMS2, and MSH6) bring the total number of genes suspected to cause hereditary OC to 11.
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Barbara M. Norquist
Maria I. Harrell
Mark F. Brady
JAMA Oncology
Harvard University
University of Washington
University of Pennsylvania
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Norquist et al. (Thu,) studied this question.
www.synapsesocial.com/papers/69d73537779571b57e48f4f1 — DOI: https://doi.org/10.1001/jamaoncol.2015.5495