Does adiponectin signaling regulate myocardial oxidative stress in humans?
Humans
Adiponectin signaling
Myocardial nicotinamide adenine dinucleotide phosphate oxidase activity and adiponectin expression in epicardial adipose tissue (EpAT)surrogate
This study provides the first evidence in humans of a mutual regulatory mechanism between epicardial adipose tissue and the heart to defend against oxidative stress via adiponectin.
We demonstrate for the first time in humans that adiponectin directly decreases myocardial nicotinamide adenine dinucleotide phosphate oxidase activity via endocrine or paracrine effects. Adiponectin expression in EpAT is controlled by paracrine effects of oxidation products released from the heart. These effects constitute a novel defense mechanism of the heart against myocardial oxidative stress.
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Alexios S. Antonopoulos
Cardiac Imaging
Marios Margaritis
University College London Hospitals NHS Foundation Trust
Sander Verheule
Electrophysiology
Circulation Research
King's College London
Maastricht University
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Antonopoulos et al. (Mon,) studied this question.
synapsesocial.com/papers/69d763b4ecaf04fa2648f3b7 — DOI: https://doi.org/10.1161/circresaha.115.307856
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