Is carvedilol safe and effective in very elderly diabetic patients with heart failure?
Carvedilol is safe and effective in very elderly diabetic patients with heart failure, although diabetes limits the extent of left ventricular systolic dysfunction reversibility.
Similarly to younger ones, also in older patients, diabetes does not negatively influence the safety, tolerability and efficacy of carvedilol. However, diabetes remains a strong prognostic factor limiting the reversibility of left ventricular systolic dysfunction and the effect of treatment on subsequent outcome.
Sindaco et al. (Sat,) studied this question.