Why the study?
Is carvedilol safe and effective in very elderly diabetic patients with heart failure?
Is carvedilol safe and effective in very elderly diabetic patients with heart failure?
Carvedilol is safe and effective in very elderly diabetic patients with heart failure, although diabetes limits the extent of left ventricular systolic dysfunction reversibility.
May support carvedilol in elderly diabetic HF; leaves open diabetes effects on LV recovery in prospective studies.
Similarly to younger ones, also in older patients, diabetes does not negatively influence the safety, tolerability and efficacy of carvedilol. However, diabetes remains a strong prognostic factor limiting the reversibility of left ventricular systolic dysfunction and the effect of treatment on subsequent outcome.
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Sindaco et al. (2007) studied this question.
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