Primary aldosteronism was associated with significantly higher peripheral pulse wave velocity compared to essential hypertension (11.59 vs. 10.70 m/s, p=0.002), indicating increased peripheral arterial stiffness.
Case-Control (n=98)
No
Does primary aldosteronism increase peripheral arterial stiffness compared to essential hypertension?
Aldosterone overproduction in primary aldosteronism increases both central and peripheral arterial stiffness compared to essential hypertension, suggesting a fibroproliferative effect on muscular arteries.
Absolute Event Rate: 11.59% vs 10.7%
p-value: p=0.002
Aldosterone overproduction increases arterial wall stiffness by accumulation of different types of collagen fibres and growth factors. Our previous studies showed that central (aortic) arterial stiffness is increased in primary aldosteronism (PA) independently of concomitant hypertension and that these changes might be reversible after successful adrenalectomy. There is limited data available on the potential impact of mineralocorticoid overproduction on the deterioration of peripheral arterial stiffness. The current study was thus aimed at investigating the effect of aldosterone overproduction on peripheral arterial stiffness assessed by peripheral (femoral-ankle) pulse wave velocity (PWV) in PA patients compared with essential hypertension (EH) patients. Forty-nine patients with confirmed PA and 49 patients with EH were matched for age, blood pressure, body mass index, lipid profile, and fasting glucose. PWV was obtained using the Sphygmocor applanation tonometer. Both peripheral and central PWV were significantly higher in PA patients compared to EH patients, while clinical blood pressures were similar. Plasma aldosterone level was the main predictor of peripheral PWV in PA. Our data indicate aldosterone overproduction in PA does not preferentially affect central arterial system. Fibroproliferative effect of higher aldosterone levels lead to alteration of central-elastic as well as peripheral-muscular arteries with subsequent increase in its stiffness.
Rosa et al. (Wed,) conducted a case-control in Primary Aldosteronism (n=98). Primary Aldosteronism vs. Essential Hypertension was evaluated on Peripheral (femoral-ankle) pulse wave velocity (m/s) (p=0.002). Primary aldosteronism was associated with significantly higher peripheral pulse wave velocity compared to essential hypertension (11.59 vs. 10.70 m/s, p=0.002), indicating increased peripheral arterial stiffness.
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