Calcific aortic valve disease (CAVD)
Spatiotemporal multi-omics mapping and network/systems biology strategy
Identification of molecular regulatory networks in CAVD
A multi-omics strategy successfully mapped the molecular regulatory networks driving calcific aortic valve disease, providing a novel framework for cardiovascular disease ontology.
A spatially and temporally resolved multi-omics, and network and systems biology strategy identifies the first molecular regulatory networks in CAVD, a cardiac condition without a pharmacological cure, and describes a novel means of systematic disease ontology that is broadly applicable to comprehensive omics studies of cardiovascular diseases.
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Florian Schlotter
Structural Heart Disease
Arda Halu
Brigham and Women's Hospital
Shinji Goto
Senko Medical Instrument Manufacturing (Japan)
Circulation
Rogers (United States)
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Schlotter et al. (Tue,) studied this question.
synapsesocial.com/papers/69b31ef1033832e42976e18f — DOI: https://doi.org/10.1161/circulationaha.117.032291