Patients with diabetes mellitus presenting with acute coronary syndromes had a higher prevalence of lipid-rich plaque in culprit lesions compared to those without diabetes (58.9% vs 44.9%, P=0.030).
Observational (n=322)
Do patients with diabetes mellitus presenting with acute coronary syndromes have more vulnerable coronary plaque characteristics compared to those without diabetes?
Patients with diabetes presenting with acute coronary syndromes exhibit more vulnerable plaque features in both culprit and nonculprit lesions on optical coherence tomography, indicating greater panvascular instability.
Absolute Event Rate: 58.9% vs 44.9%
p-value: p=0.030
Background Diabetes mellitus ( DM ) is a major risk factor for cardiovascular events. We aimed to investigate the coronary plaque phenotype of diabetic patients who presented with acute coronary syndromes by optical coherence tomography. Methods and Results A total of 322 patients with acute coronary syndromes who underwent preintervention optical coherence tomography imaging of the culprit lesion were included. Culprit plaque characteristics were compared between patients with DM (n=95) and those without DM (n=227). In the subgroup of 250 patients in whom sufficient length of nonculprit region in the culprit vessel was imaged by optical coherence tomography, the characteristics of nonculprit plaques were also evaluated. Patients with DM had a higher prevalence of lipid‐rich plaque (58.9% versus 44.9%, P =0.030) and macrophage accumulation (60.0% versus 44.9%, P =0.019) in the culprit lesion compared with patients without DM . The prevalence of plaque rupture (33.7% versus 30.4%, P =0.896) and plaque erosion (21.1% versus 22.0%, P =0.458) was similar. In the nonculprit lesions, the DM group had greater maximal lipid arc (248.9°±83.9° versus 179.9°±58.3°, P =0.006), thinner fibrous cap thickness (103.3±56.2 μm versus 140.7±70.0 μm, P =0.013), and a higher prevalence of thin‐cap fibroatheroma (17.2% versus 6.3%, P =0.031), compared with the non‐ DM group. Conclusions Compared with patients without DM , those with DM had more vulnerable features in both culprit and nonculprit lesions, thus indicating a higher level of panvascular instability. Clinical Trial Registration URL : http://www.clinicaltrials.gov . Unique identifier: NCT 01110538.
Sugiyama et al. (Fri,) conducted a observational in Acute coronary syndromes (n=322). Diabetes Mellitus vs. No Diabetes Mellitus was evaluated on Prevalence of lipid-rich plaque in the culprit lesion (p=0.030). Patients with diabetes mellitus presenting with acute coronary syndromes had a higher prevalence of lipid-rich plaque in culprit lesions compared to those without diabetes (58.9% vs 44.9%, P=0.030).