September 16, 2018Open Access
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly
Structured PICO
Does low-dose aspirin prevent cardiovascular disease in healthy older adults?
P
Population
Healthy older adults
I
Intervention
Low-dose aspirin
C
Comparator
Placebo
O
Outcome
Cardiovascular disease and major hemorrhagehard clinical
Low-dose aspirin is not effective for primary cardiovascular prevention in healthy older adults and significantly increases the risk of major hemorrhage.
Abstract
The use of low-dose aspirin as a primary prevention strategy in older adults resulted in a significantly higher risk of major hemorrhage and did not result in a significantly lower risk of cardiovascular disease than placebo. (Funded by the National Institute on Aging and others; ASPREE ClinicalTrials.gov number, NCT01038583 .).
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Authors
John J. McNeil
General Cardiology
R
Rory Wolfe
Preventive Cardiology
R
Robyn L. Woods
Preventive Cardiology
Journals
New England Journal of Medicine
Actions
Institutions
University of Minnesota
The University of Melbourne
Brown University
References and Citations
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