In three patients with cardiac complications after immune checkpoint inhibitor therapy, unique cytokine activation profiles were observed, with IL-8 being predominantly elevated.
Case Report (n=3)
Unique cytokine activation patterns, particularly involving IL-8, may reflect the severity and specific type of cardiac complications following immune checkpoint inhibitor therapy.
We herein report the cytokine expression at different stages for three patients who developed cardiac complications after immune checkpoint inhibitor (ICI) therapy. Case 1 with biopsy-proven myocarditis showed increased levels of interleukin (IL)-8, monocyte chemotactic and activating factor, and granulocyte macrophage colony-stimulating factor (GM-CSF) when he developed Takotsubo cardiomyopathy. Case 2 with subclinical myocarditis showed predominant activation of IL-8 during the progressive clinical course. Case 3 with cytokine-releasing syndrome showed substantial activations of IL-6, IL-8, GM-CSF, and interferon-γ. Our data suggest the development of unique cytokine activation in individual patients with cardiac complications after ICI therapy.
Tsuruda et al. (Fri,) conducted a case report in Cardiac complications after immune checkpoint inhibitor therapy (n=3). Immune checkpoint inhibitors (pembrolizumab, nivolumab) was evaluated on Cytokine expression levels. In three patients with cardiac complications after immune checkpoint inhibitor therapy, unique cytokine activation profiles were observed, with IL-8 being predominantly elevated.