High fasting blood glucose was significantly associated with an increased risk of incident hypertension over a 7-year follow-up (aHR 1.836; 95% CI 1.810 to 1.862).
Cohort (n=3,396,187)
Does high fasting blood glucose predict incident hypertension in non-hypertensive subjects?
High fasting blood glucose and prediabetes are independent risk factors for the development of hypertension in a large real-world Korean cohort.
Effect estimate: aHR 1.836 (95% CI 1.810 to 1.862)
This retrospective cohort study was done to investigate the incidence of hypertension and its relation to the fasting blood glucose level in Korea. The eligible non-hypertensive subjects (n = 3,396,187) among the National Health Insurance Service-National Health Screening (NHIS-HEALS) examinees (n = 10,644,911) in 2009 were followed up until 2015. A Cox proportional hazards regression was used to estimate the risk of the high blood glucose level for the incident hypertension while controlling for covariates’ confounding effect. The cumulative incidence rate was 10.6% for seven years (11.6% in men and 8.3% in women). The incidence density was 1474.8 per 100,000 person-years. High fasting blood glucose (adjusted Hazard Ratio (aHR), 1.836; 95% confidence interval (CI), 1.810 to 1.862), prediabetes (aHR, 1.249; 95% CI, 1.237 to 1.260), a history of diabetes mellitus (aHR, 1.635; 95% CI, 1.605 to 1.666), high triglyceride (aHR, 1.292; 95% CI, 1.280 to 1.303), a history of dyslipidemia (aHR, 1.279; 95% CI, 1.253 to 1.305) and prehypertension group (aHR, 1.964; 95% CI, 1.948 to 1.979) were significantly related to the incident hypertension after adjusting for covariates. Among real-world data in Korea, high blood glucose level was the independent risk factor for developing hypertension.
Ahn et al. (Sun,) conducted a cohort in Non-hypertensive subjects (n=3,396,187). High fasting blood glucose was evaluated on Incident hypertension (aHR 1.836, 95% CI 1.810 to 1.862). High fasting blood glucose was significantly associated with an increased risk of incident hypertension over a 7-year follow-up (aHR 1.836; 95% CI 1.810 to 1.862).
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