Key result
High fasting blood glucose is linked to ~84% higher incident hypertension risk over 7 years.
Why the study?
The study was conducted to investigate the incidence of hypertension and its relation to fasting blood glucose levels in Korea.
Does high fasting blood glucose increase the risk of incident hypertension in non-hypertensive adults?
Cohort (n=3,396,187)
Does high fasting blood glucose increase the risk of incident hypertension in non-hypertensive adults?
High fasting blood glucose and prediabetes are independent risk factors for developing incident hypertension in a large, real-world Korean cohort.
Answers are grounded in this paper and cite their sources.
May warrant glucose monitoring for hypertension risk stratification; extends large cohort data but leaves causal prevention trials open.
This retrospective cohort study was done to investigate the incidence of hypertension and its relation to the fasting blood glucose level in Korea. The eligible non-hypertensive subjects (n = 3,396,187) among the National Health Insurance Service-National Health Screening (NHIS-HEALS) examinees (n = 10,644,911) in 2009 were followed up until 2015. A Cox proportional hazards regression was used to estimate the risk of the high blood glucose level for the incident hypertension while controlling for covariates’ confounding effect. The cumulative incidence rate was 10.6% for seven years (11.6% in men and 8.3% in women). The incidence density was 1474.8 per 100,000 person-years. High fasting blood glucose (adjusted Hazard Ratio (aHR), 1.836; 95% confidence interval (CI), 1.810 to 1.862), prediabetes (aHR, 1.249; 95% CI, 1.237 to 1.260), a history of diabetes mellitus (aHR, 1.635; 95% CI, 1.605 to 1.666), high triglyceride (aHR, 1.292; 95% CI, 1.280 to 1.303), a history of dyslipidemia (aHR, 1.279; 95% CI, 1.253 to 1.305) and prehypertension group (aHR, 1.964; 95% CI, 1.948 to 1.979) were significantly related to the incident hypertension after adjusting for covariates. Among real-world data in Korea, high blood glucose level was the independent risk factor for developing hypertension.
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Ahn et al. (2021) conducted a cohort in Non-hypertensive adults (n=3,396,187). High fasting blood glucose (≥126 mg/dL) vs. Normal fasting blood glucose (<100 mg/dL) was evaluated on Incident hypertension (aHR 1.836, 95% CI 1.810-1.862). High fasting blood glucose independently increased the risk of developing incident hypertension by 84% compared to normal blood glucose levels over a 7-year follow-up.
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