Impaired cardiac baroreflex effectiveness during provoked blood pressure fluctuations was associated with poorer functional capacity in nonhypoxemic PAH, and was not mediated by the peripheral chemoreflex.
Observational
Does the peripheral chemoreflex play a role in cardiac baroreflex dysfunction in patients with pulmonary arterial hypertension (PAH)?
In patients with nonhypoxemic PAH, cardiac baroreflex dysfunction is present and associated with poorer functional capacity, but is not mediated by the peripheral chemoreflex.
Does the peripheral chemoreflex play a role in cardiac baroreflex dysfunction in patients with pulmonary arterial hypertension (PAH)? Here we provide new evidence of cardiac baroreflex dysfunction under spontaneous and, most notably, provoked blood pressure fluctuations in patients with nonhypoxemic PAH. Importantly, impaired cardiac baroreflex effectiveness during provoked blood pressure fluctuations was independently associated with poorer functional capacity. Finally, our results indicated that the peripheral chemoreflex did not mediate cardiac baroreflex dysfunction among those patients.
Paula‐Ribeiro et al. (Thu,) conducted a observational in Pulmonary arterial hypertension. Peripheral chemoreflex was evaluated on Cardiac baroreflex dysfunction and functional capacity. Impaired cardiac baroreflex effectiveness during provoked blood pressure fluctuations was associated with poorer functional capacity in nonhypoxemic PAH, and was not mediated by the peripheral chemoreflex.
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