Correlation between perivascular adipose tissue surrounding coronary arteries measured on coronary artery CT Angiography and the presence and severity of CAD

Background:The aim of this study was to explore the relationship between pericoronary adipose tissue volume (V-PCAT), as assessed via coronary artery CT angiography (CCTA), and the presence and severity of coronary artery disease (CAD). Materials and Methods:A retrospective analysis was conducted on 160 individuals with suspected CAD who underwent CCTA from June 2020 to December 2021.Quantification of both epicardial adipose tissue volume (V-EAT) and V-PCAT was performed.Clinical data, lipid metrics, and differences in adipose tissue volume between CAD and non-CAD groups were assessed.Variables influencing CAD were analyzed using univariate and multivariate logistic regression.The diagnostic accuracy of adipose tissue volume in predicting CAD was determined through receiver operating characteristic curves.The association between adipose tissue volume and coronary artery stenosis severity was investigated.Results: The analysis included 100 patients with CAD and 60 without CAD.V-EAT and V-PCAT were notably higher in the CAD group than the without CAD group.After adjustments for confounding factors, V-EAT and V-PCAT showed a positive association with CAD.The area under the curve of V-PCAT was 0.875.Conclusions: V-PCAT, measured via CCTA was substantial associated with CAD while serving as an independent risk determinant.Additionally, V-PCAT, notably correlated with the severity of coronary artery stenosis.