High-intensity interval training produced the largest change in VO2max (0.43 ± 0.20 L/min) compared to control (0.02 ± 0.08 L/min; P<0.05), supported predominantly by central adaptations.
RCT (n=84)
age- and sex-matched
Does intensity domain-specific endurance training improve V̇O2max and central/peripheral adaptations in young healthy participants?
Higher training intensities (upper heavy and severe/HIIT) produce the largest improvements in V̇O2max, driven predominantly by central rather than peripheral adaptations.
p-value: p=< 0.05
PURPOSE: This study characterized central and peripheral adaptations to domain-specific endurance exercise training. METHODS: Eighty-four young healthy participants were randomly assigned to age- and sex-matched groups of: continuous cycling in the 1) moderate-intensity (MOD), 2) lower heavy-intensity (HVY1), and 3) upper heavy-intensity (HVY2) domain; interval cycling in the 4) severe-intensity domain (i.e., high-intensity interval training (HIIT), and 5) extreme-intensity domain (i.e., sprint-interval training (SIT)); or 6) control (CON). Two 3-wk phases of training (three sessions per week) were performed. All training protocols, except SIT, were work matched. RESULTS: Maximal oxygen uptake (V̇O 2max ), maximal cardiac output (Q˙ max ), derived maximal arterial-venous oxygen difference (a-vO 2diff ), blood volume (BV), plasma volume (PV), and near-infrared spectroscopy (NIRS)-derived muscle oxidative capacity (τOxCap) were measured and compared at PRE and POST. The largest change in V̇O 2max occurred in HIIT (0.43 ± 0.20 L·min -1 ), which was greater than CON (0.02 ± 0.08 L·min -1 ), MOD (0.11 ± 0.19 L·min -1 ), HVY1 (0.24 ± 0.18 L·min -1 ), and SIT (0.28 ± 0.21 L·min -1 ) ( P 0.05). Changes in Q˙ max were observed in HVY1 (1.6 ± 0.5 L·min -1 ), HVY2 (3.0 ± 0.6 L·min -1 ), HIIT (2.9 ± 1.2 L·min -1 ), and SIT (1.8 ± 1.4 L·min -1 ) ( P 0.05). HVY2 and HIIT produced significant changes in BV (438 ± 101 and 302 ± 38 mL) and PV (198 ± 92 and 158 ± 51 mL), respectively ( P 0.05). The results indicate that higher training intensities (i.e., HVY2 and HIIT) produce larger changes in V̇O 2max , which is supported predominantly by central adaptations. In addition, results suggest that, despite nonsignificant changes, the contribution of peripheral components to changes in V̇O 2max should not be dismissed.
Inglis et al. (Thu,) conducted a rct in Healthy (n=84). Domain-specific endurance exercise training (MOD, HVY1, HVY2, HIIT, SIT) vs. Control was evaluated on Change in maximal oxygen uptake (VO2max) (p=< 0.05). High-intensity interval training produced the largest change in VO2max (0.43 ± 0.20 L/min) compared to control (0.02 ± 0.08 L/min; P<0.05), supported predominantly by central adaptations.
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