Mild paravalvular leak after TAVR was not associated with adverse clinical outcomes or significant impairment in cardiac remodeling at 2 years compared to no/trace leak (P=0.67).
Cohort (n=2,601)
No
Does mild paravalvular leak worsen 2-year clinical outcomes and hemodynamics in adult patients following TAVR?
2601 adult patients who underwent transcatheter aortic valve replacement (TAVR) at the Cleveland Clinic between January 2016 and July 2021
Mild postprocedural paravalvular leak (PVL)
No or trace postprocedural paravalvular leak (PVL)
2-year clinical outcomes, including all-cause mortality and heart failure hospitalizations, and hemodynamic changeshard clinical
Mild paravalvular leak following TAVR does not adversely affect 2-year clinical outcomes or cardiac remodeling compared to no or trace leak.
p-value: p=0.67
Background: Paravalvular leak (PVL) remains a frequent complication of transcatheter aortic valve replacement (TAVR). The long-term consequences of mild PVL on outcomes have been debated. This study aimed to investigate the clinical and hemodynamic outcomes of mild PVL over a 2-year period. Methods: We conducted a retrospective cohort study of 2601 adult patients who underwent TAVR at the Cleveland Clinic between January 2016 and July 2021. Patients were categorized based on postprocedural PVL severity (mild vs. no/trace PVL). Differences in 2-year clinical outcomes, including all-cause mortality and heart failure hospitalizations, were assessed using Cox regression analysis, while hemodynamic changes were analyzed with a linear mixed model. Results: = 0.67). Conclusions: Mild PVL after TAVR is not associated with adverse long-term clinical outcomes or significant impairment in cardiac remodeling within the first 2 years postprocedure compared to no/trace PVL.
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Akiva Rosenzveig
Interventional Cardiology
Shivabalan Kathavarayan Ramu
Cleveland Clinic
Besir Besir
Interventional / Structural Cardiology
Structural Heart
Cleveland Clinic
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Rosenzveig et al. (Thu,) conducted a cohort in Transcatheter aortic valve replacement (n=2,601). Mild paravalvular leak vs. No/trace paravalvular leak was evaluated on All-cause mortality and heart failure hospitalizations (p=0.67). Mild paravalvular leak after TAVR was not associated with adverse clinical outcomes or significant impairment in cardiac remodeling at 2 years compared to no/trace leak (P=0.67).
synapsesocial.com/papers/6a0f64184fb650da4ffe1b4f — DOI: https://doi.org/10.1016/j.shj.2025.100464
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