Key result
Mild paravalvular leak after TAVR is not linked to adverse clinical outcomes at 2 years.
Why the study?
Paravalvular leak remains a frequent complication of TAVR, and the long-term consequences of mild PVL on clinical and hemodynamic outcomes have been debated.
Does mild paravalvular leak worsen 2-year clinical outcomes and hemodynamics in adult patients following TAVR?
Population
2601 adult patients who underwent TAVR at the Cleveland Clinic between January 2016 and July 2021
Comparison
Mild PVL vs no/trace PVL
Design
Retrospective cohort study
Follow-up
2 years
Authors
Loading...
Mild paravalvular leak after TAVR need not prompt intervention; leaves open confirmation in randomized trials.
Cohort (n=2,601)
No
Does mild paravalvular leak worsen 2-year clinical outcomes and hemodynamics in adult patients following TAVR?
p-value: p=0.67
Mild paravalvular leak following TAVR does not adversely affect 2-year clinical outcomes or cardiac remodeling compared to no or trace leak.
Rosenzveig et al. (2025) conducted a cohort in Transcatheter aortic valve replacement (n=2,601). Mild paravalvular leak vs. No/trace paravalvular leak was evaluated on All-cause mortality and heart failure hospitalizations (p=0.67). Mild paravalvular leak after TAVR was not associated with adverse clinical outcomes or significant impairment in cardiac remodeling at 2 years compared to no/trace leak (P=0.67).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: