Key result
Periprocedural PVL post-TAVI is linked to ~190% higher inpatient mortality and increased 180-day readmissions.
Why the study?
Periprocedural prosthetic valve leak after TAVI may entail serious morbidity, but its impact on clinical outcomes, readmissions, and healthcare costs warrants evaluation.
Does periprocedural prosthetic valve leak after TAVI increase mortality, morbidity, and readmission rates in patients with severe aortic stenosis?
Population
319,448 TAVI patients hospitalized from a national database (2016-2020)
Comparison
TAVI with periprocedural PVL vs without PVL
Design
Propensity score-matched national database cohort study
Follow-up
180-day
Authors
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Periprocedural PVL after TAVI was associated with higher acute HF; leaves open whether targeted leak mitigation improves outcomes.
Cohort (n=319,448)
Yes
Does periprocedural prosthetic valve leak after TAVI increase mortality, morbidity, and readmission rates in patients with severe aortic stenosis?
Absolute Event Rate: 3.05% vs 1.05%
p-value: p=<0.001
Periprocedural prosthetic valve leak after TAVI is associated with significantly increased inpatient mortality, periprocedural complications, and up to 180-day readmission rates, highlighting the need for optimal valve deployment.
Ali et al. (2025) conducted a cohort in severe, symptomatic aortic stenosis (n=319,448). Periprocedural prosthetic valve leak vs. TAVI without prosthetic valve leak was evaluated on inpatient mortality (p=<0.001). Periprocedural prosthetic valve leak after TAVI was associated with higher inpatient mortality (3.05% vs. 1.05%, p<0.001) and increased 180-day readmission (34.7% vs. 24.8%, p<0.01).
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