Figure S6 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

Key Points

• mTOR inhibition triggers ferritinophagy and ferroptosis in head and neck cancer cells, fostering cell death.
• Evidence shows mTOR inhibition significantly impacts ferritinophagy and ferroptosis pathways in cancerous cells.
• Analysis involved genome-wide CRISPR screening to assess the role of mTOR and its effects on ferritinophagy.
• These findings highlight mTOR's potential as a target for therapies aimed at treating head and neck cancer.

Abstract