Figure S17 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

Key Points

• Tumor control is significantly enhanced when combining mTOR inhibitors and auranofin in vivo.
• The study reveals that mTOR inhibition triggers ferritinophagy and ferroptosis in head and neck cancer models.
• This observational analysis incorporated various cancer models to see the effects of mTOR inhibition.
• These findings highlight the potential for new therapeutic strategies targeting mTOR in cancer treatment.

Abstract