Figure S16 from Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer

Key Points

• mTOR inhibition triggers ferroptosis, showing a possible new pathway in cancer treatment.
• Ferrostatin-1 lessened mTOR inhibitor effects, evidencing its role in cell death processes.
• Genome-wide CRISPR screening was employed to identify key pathways and mechanisms in head and neck cancer.
• These findings suggest that targeting ferritinophagy may enhance therapeutic approaches and improve outcomes.

Abstract