Figure S19 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Key Points

• TGFβ signaling was significantly decreased in tumors receiving RER compared to those treated with only radiation therapy.
• The combination of TGFβ inhibition and radiation therapy enhanced immune cell infiltration within the tumors.
• Observed reductions in metastases were linked to the combined treatment approach, indicating potential therapeutic benefits.
• This study utilizes a mouse model to investigate the effects of TGFβ inhibition in Ewing sarcoma during radiation therapy.