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September 17, 2025

3D Single-Slab and Multi-Slab DWI Using 3D Accelerated MUSER (3D-AccMUSER) with Spectrum Analysis and Variable-Density CAIPI

Key Points

The novel 3D-AccMUSER achieves greater slab thickness, enhancing SNR efficiency in diffusion-weighted imaging.
Results show a nearly threefold reduction in scan time, enabling quicker and more efficient imaging processes.
This approach combines 3D MUSER with sliding-slab techniques to address limitations of existing methods effectively.
Significant implications include better evaluation of complex white matter structures, aiding neuroscience research.

Abstract

Motivation: Sliding-slab profile encoding (SLIPEN) as a 3D multi-slab DWI technique with 2D navigator suffers from limited slab thickness and limited SNR. Goal(s): To address the limitation of slab thickness and SNR in SLIPEN and optimize the acceleration. Approach: 3D-MUSER with 3D navigator was combined with sliding-slab technique (3D-ms-AccMUSER) to improve the attainable slab thickness and SNR without suffering slab boundary artifacts. A spectrum-analysis-based variable-density CAIPI pattern is proposed for optimizing the acceleration. Results: The proposed 3D-AccMUSER can achieve flexible slab thickness for improving the SNR efficiency, and clearly depict white-matter structure. Its accelerated version can reduce the scan time by almost three times. Impact: 3D isotropic high-resolution DWI with better SNR efficiency and clear white matter structure can be robustly achieved by our method at 1.5T, therefore benefiting the neuroscience study in evaluating crossing and kissing fibers.

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3D Single-Slab and Multi-Slab DWI Using 3D Accelerated MUSER (3D-AccMUSER) with Spectrum Analysis and Variable-Density CAIPI

Key Points

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