Supplementary figure 7 from Nrf2 Hyperactivation as a Driver of Radiotherapy Resistance and Suppressed Antitumor Immunity in Head and Neck Squamous Cell Carcinoma

Key Points

• Nrf2 knockdown in Keap1-deficient HNSCC cell lines increased radiotherapy sensitivity, highlighting its role in resistance.
• The study observed a notable reduction in tumor growth when nrf2 was targeted, suggesting a link to antitumor immunity.
• Experimental analysis focused on cell response to radiotherapy in genetically modified murine models, revealing key insights.
• Findings support the potential for targeting nrf2 to enhance radiotherapy outcomes in head and neck cancer treatment.